ceesdekker Can Be Fun For Anyone
ceesdekker Can Be Fun For Anyone
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‘Indeed, that is about proper. I try to find a physical comprehension of Organic techniques in a very bottom-up way. I believe you could possibly distinguish a few lines of investigation in my team in the intervening time. The first considerations chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation procedures that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
Our group research bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Because 2000, Dekker has shifted the leading focus of his perform to biophysics exactly where he reports the Houses of one biomolecules and cells using the resources of nanotechnology. This modification of field was driven by his fascination to the extraordinary functioning of biological molecular constructions, together with via the lengthy-phrase point of view a large number of interesting discoveries could be anticipated In this particular discipline.[five] Latest strains of investigate in his biophysics team are during the areas of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initially ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
What distinguishes biology from chemistry is always that these components jointly make up a living process. The secret of claimed existence, I do think, lies within the interactions, the interaction of These molecules. The large question with regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from straightforward molecules into your incredibly advanced methods we see currently? We have no idea. I would like to work on ceesdekker.net these kinds of major, open up queries.’
2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore intricate; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
The rotors harness Electrical power from the nanoscale water and ion move that's created by a static chemical or electrochemical probable gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to developing Strength-transducing motors at nanoscale interfaces.
It was in the course of this era that Dekker completed exploration on magnetic spin systems and on noise in superconductors and semiconductors.
An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA fix complexes; and to start with force measurements over a DNA molecule in a nanopore
Finally, I will briefly sketch a few of our Tips to check out the making of artificial cells, specially our to start with steps to establish artificial mobile division.